TREATMENT OF TUMOURS BY ADOPTIVE TRANSFER OF CD44v-SPECIFIC CYTOTOXIC T-LYMPHOCYTES

摘要: The invention concerns a fusion protein containing first portion having specific affinity for an amino acid sequence which is coded by variant exon of the CD44 gene, and second contains subunit T-cell receptor complex or immunoglobulin part this subunit. Preferably, variable domain antibody (CD44v), in particular CD44v6. further nucleic molecule codes such protein. substances according to are suitable treating tumours adoptive transfer cytotoxic T-lymphocytes destroy tumour cells expressing one plurality epitopes gene on their cell surface. For example, can be introduced into corresponding lymphocytes thus modified administered patient.