Staphylococcus aureus sepsis and the waterhouse- friderichsen syndrome in children

作者: Patricia V. Adem , Christopher P. Montgomery , Aliya N. Husain , Tracy K. Koogler , Valerie Arangelovich

DOI: 10.1056/NEJMOA044194

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摘要: Staphylococcus aureus has increasingly been recognized as a cause of severe invasive illness. We describe three children who died at our institution after rapidly progressive clinical deterioration from this infection, with necrotizing pneumonia and multiple-organ-system involvement. The identification bilateral adrenal hemorrhage autopsy was characteristic the Waterhouse–Friderichsen syndrome, constellation findings usually associated fulminant meningococcemia. close genetic relationship among responsible isolates S. aureus, one susceptible to methicillin two resistant methicillin, underscores between virulent methicillin-susceptible methicillin-resistant now circulating in community.

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