E proteins and the regulation of early lymphocyte development

摘要: Lymphopoiesis generates mature B, T, and NK lymphocytes from hematopoietic stem cells via a series of increasingly restricted developmental intermediates. The transcriptional networks that regulate these fate choices are composed both common lineage-specific components, which combine to create cellular context informs the response external signals. E proteins an important factor during lymphopoiesis, E2A in particular is required for normal T- B-cell development. Although other proteins, HEB E2-2, expressed lymphopoiesis can compensate some E2A's activity, have non-redundant functions early T-cell development at multiple checkpoints throughout B lymphopoiesis. More recently, role has been demonstrated generation lymphoid-primed multipotent progenitors shown favor their specification toward lymphoid over myeloid lineages. This review summarizes our current understanding wide-ranging adaptive novel orchestrating lymphoid-biased progenitors.