Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats.

摘要: It was well established that compounds which decrease glutamatergic transmission via blockade of NMDA or group I mGlu receptors produce anxiolytic- and antidepressant-like action in animal tests models. Since III metabotropic glutamate receptor (mGluR) agonists are known to reduce neurotransmission by the inhibition release, we decided investigate potential and/or effects mGluR agonists, after central administration rats. found (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid (ACPT-I) 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric (HomoAMPA), given intrahippocampally, produced a dose-dependent anxiolytic-like effect conflict drinking test. The ACPT-I HomoAMPA were reversed (RS)-alpha-cyclopropyl-4-phosphonophenyl glycine (CPPG), antagonist. Moreover, (RS)-4-phosphonophenylglycine (RS-PPG), but not HomoAMPA, behavioral despair test, intracerebroventricular injections, CPPG. results obtained indicate as tests, reduction release activation may be possible mechanism underlying properties tested compounds. In conclusion, our studies play role therapy both anxiety depression.