Rickenyls A-E, antioxidative terphenyls from the fungus Hypoxylon rickii (Xylariaceae, Ascomycota).
作者： Eric Kuhnert , Frank Surup , Jennifer Herrmann , Volker Huch , Rolf Müller
DOI: 10.1016/J.PHYTOCHEM.2015.08.004
关键词:
摘要: Our screening efforts for new natural products with interesting bioactivity have revealed the neotropical ascomycete Hypoxylon rickii as a prolific source. We isolated five secondary metabolites p-terphenyl backbone from mycelial extract of fermentation this fungus in 70 l scale by using RP-HPLC, which were named rickenyls A-E (1-5). Their structures elucidated X-ray crystallography and NMR spectroscopy, complemented HRESIMS. Two compounds contained quinone core structure ortho (2) para-position (5), respectively. obtained 2 spontaneously lead tetraacetate oxidation 1. All screened antimicrobial, antioxidative cytotoxic activities. Rickenyl A (1) exhibited strong effects moderate activity against various cancer cell lines.
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