The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study.

摘要: Background:  The atopy patch test (APT) was proposed to evaluate IgE-mediated sensitizations in patients with atopic eczema (AE). Objective:  prevalence and agreement clinical history specific IgE (sIgE) of positive APT reactions investigated six European countries using a standardized method. Methods:  A total 314 AE remission were tested 12 study centers on clinically uninvolved, non-abraded back skin 200 index reactivity (IR)/g house dust mite Dermatophagoides pteronyssinus, cat dander, grass, birch pollen allergen extracts defined major contents petrolatum. Extracts egg white, celery wheat flour protein content also tested. values evaluated at 24, 48, 72 h according the Task Force Atopic Dermatitis (ETFAD) guidelines. In addition, skin-prick (SPT) sIgE detailed allergen-induced flares obtained. Results:  Previous flares, after contact allergens, reported 1% (celery) 34% (D. pteronyssinus) patients. frequency clear-cut ranged from 39% D. pteronyssinus 9% celery. All ETFAD intensities occured 48 72 h. Positive SPT (16–57%) elevated (19–59%) results more frequent. Clear-cut all testing negative seen 7% patients, whereas without or for respective 17% APT, showed significant grass white (two-sided Pr > |Z| ≤ 0.01). other aeroallergens. With regard history, had higher specificity (64–91% depending allergen) than (50–85%) (52–85%). associated longer duration regional differences. 10 non-atopic controls, no reaction seen. Conclusion:  Aeroallergens food allergens are able elicit eczematous epicutaneous application. As gold standard aeroallergen provocation exists, relevance aeroallergens may be by addition sIgE. data contribute international standardization APT.