Unilateral adrenal hyperplasia: A novel cause of surgically correctable primary hyperaldosteronism

摘要: Background Primary hyperaldosteronism may be caused by an aldosterone-producing adenoma (APA), which is correctable unilateral adrenalectomy or idiopathic adrenal hyperplasia, a bilateral disease without any indication for surgery. This study sought to assess the prevalence and results of surgery in hyperplasia (UAH). Methods The included 35 patients who underwent because primary after unequivocal successful lateralization venous sampling. Demographics, biochemical evaluation, blood pressure were assessed pre- postoperatively. Pathology was categorized as APA (isolated adenoma), nodular (multiple micromacronodules), diffuse UAH (gland thickening nodules). Results revealed 9 APAs 23 3 UAHs. Patients with UAHs statistically similar regarding demographics preoperative levels. Bilateral involvement evident at imaging 10 (11% versus 35% UAH, P = NS). After surgery, cure achieved all patients; levels normalized 66.6% ameliorated 22.2% 34.6% 50% ( = NS). At long-term follow-up, only 1 patient experienced recurrence disease. Conclusion not rare, sharing same features APA. When confirmed sampling, achieves excellent results.