Glial kon/NG2 gene network for central nervous system repair

摘要: The glial regenerative response to central nervous system (CNS) injury, although limited, can be harnessed promote regeneration and repair. Injury provokes the proliferation of ensheathing cells, which differentiate remyelinate axons, partially restore function. This is evolutionarily conserved, strongly implying an underlying genetic mechanism. In mammals, it elicited by NG2 glia, but most often newly generated cells fail differentiate. Thus important goal had been find out how differentiation following proliferative response. A gene network involving Notch prospero (pros) controls balance between in flies mice, promotes CNS repair at least fruit-flies. key missing link relate function this network. Recent findings Losada-Perez et al., published JCB, demonstrated that Drosophila homologue kon-tiki (kon) functionally linked pros glia. By engaging two feedback loops with Pros, Kon regulate both cell number shape homeostasis, essential for offers powerful genetics unravel control stem progenitor