The effects of the alkyl polycyclic aromatic hydrocarbon retene on rainbow trout (Oncorhynchus mykiss) immune response
作者： Natacha S. Hogan , Katie S. Lee , Bernd Köllner , Michael R. van den Heuvel
DOI: 10.1016/J.AQUATOX.2010.07.020
关键词:
摘要: The objective of this study was to examine the immune toxicity alkyl polycyclic aromatic hydrocarbon (PAH) retene (7-isopropyl-1-methyl phenanthrene) in rainbow trout. Retene is a common PAH associated with combustion terrestrial plants or industrial effluents. Rainbow trout were injected intraperitoneally single dose 0, 1, 10 mg/kg and sampled at 21 d. Within each treatment, co-injection formalin-killed Aeromonas salmonicida phosphate buffered saline sham used stimulate system. At highest (10 mg/kg) there an increase total blood leukocyte counts but only A. salmonicida-injected group. This result paralleled by leukocytes differential cell counts. There overall salmonicida-specific antibody titre due antigen injection also significant stimulation production response dose. tissue level, immunohistochemistry revealed greater density B-lymphocytes spleen head kidney. A number specific transcripts including Th2 marker CD4, TCR, MHCII TNF alpha, Th1 CD8, INF gamma examined quantitative RT-PCR no influence on expression related genes either increased CD4 co-receptor observed both concentrations. appeared be mildly immunostimulatory, its own, combination inactivated challenge these data suggest that exposures fishes may not pose risk eliciting immunotoxic effects. (C) 2010 Elsevier B.V. All rights reserved
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