Succinate Dehydrogenase B Gene Mutations Predict Survival in Patients with Malignant Pheochromocytomas or Paragangliomas

作者: Laurence Amar , Eric Baudin , Nelly Burnichon , Séverine Peyrard , Stéphane Silvera

DOI: 10.1210/JC.2007-0709

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摘要: Context: Pheochromocytomas and paragangliomas may be malignant either at presentation or during recurrence, but the clinical course of tumors is unpredictable. Objective: The objective was to analyze survival according characteristics diagnosis malignancy presence absence SDHB mutations. Design: This a retrospective cohort study. Setting Participants: A total 54 patients with were included. Malignancy scored metastases histologically documented lymph node invasion. Main Outcome Measures: main outcome specific after first metastasis. Results: Germline mutations identified in (n = 23, including 21 apparent sporadic tumors) VHL 1) genes, two had neurofibromatosis 1. Patients followed up from primary tumor metastasis present death medians 79...

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