Clinical Features and Treatment Outcome of Malignant Pleural Mesothelioma.

作者: Manlio Mencoboni , Rosa A. Filiberti , Paola Taveggia , Federica Grosso , Giulia Pasello

DOI: 10.1159/000464410

关键词:

摘要: BACKGROUND Malignant pleural mesothelioma is a problematic condition due to poor prognosis and difficulties in management. We evaluated the treatment outcome of 378 patients referred 6 Italian Oncology Departments. METHODS Demographic clinical data were collected. Treatment was assessed terms chemotherapy (line treatment, pemetrexed-based regimen, other therapies), surgery, radiotherapy. Response therapy, progression-free survival, overall survival evaluated. RESULTS 36 342 received best supportive care active respectively; 86 underwent 26 trimodal therapy. Disease control after first-line achieved 74.2% (75.7% treated with pemetrexed combined drugs 69% as monotherapy). The disease rate 82.6% re-challenged individuals. Median time 11.6 months care, 16.2 only, 32.4 surgery plus chemotherapy, 47.2 A more favorable observed responders therapy who then actively second-line (24.8 vs. 11.8 non-responders, p < 0.001) third-line (28.9 17.8 = 0.005). CONCLUSION Mesothelioma benefited from alone only when retreated second line response

参考文章(25)
Xinshu Wu, Weiquan Zhang, Licun Wu, Weidong Zhang, Xiaogang Zhao, Advances in the diagnosis, treatment and prognosis of malignant pleural mesothelioma. Annals of Translational Medicine. ,vol. 3, pp. 182- 182 ,(2015) , 10.3978/J.ISSN.2305-5839.2015.07.03
Bryan M. Burt, Robert B. Cameron, Nathan M. Mollberg, Andrzej S. Kosinski, Paul H. Schipper, Joseph B. Shrager, Wickii T. Vigneswaran, Malignant pleural mesothelioma and the Society of Thoracic Surgeons Database: An analysis of surgical morbidity and mortality The Journal of Thoracic and Cardiovascular Surgery. ,vol. 148, pp. 30- 35 ,(2014) , 10.1016/J.JTCVS.2014.03.011
T M Meniawy, J Creaney, R A Lake, A K Nowak, Existing models, but not neutrophil-to-lymphocyte ratio, are prognostic in malignant mesothelioma British Journal of Cancer. ,vol. 109, pp. 1813- 1820 ,(2013) , 10.1038/BJC.2013.504
ILIR HYSI, FRANÇOISE LE PIMPEC-BARTHES, MARCO ALIFANO, NICOLAS VENISSAC, JÉRÔME MOUROUX, JEAN-FRANÇOIS REGNARD, MARC RIQUET, HENRI PORTE, Lymph node involvement and metastatic lymph node ratio influence the survival of malignant pleural mesothelioma: A French multicenter retrospective study Oncology Reports. ,vol. 31, pp. 415- 421 ,(2014) , 10.3892/OR.2013.2800
Lorenzo Spaggiari, Giuseppe Marulli, Pietro Bovolato, Marco Alloisio, Vittore Pagan, Alberto Oliaro, Giovanni Battista Ratto, Francesco Facciolo, Rocco Sacco, Daniela Brambilla, Patrick Maisonneuve, Felice Mucilli, Gabriele Alessandrini, Giacomo Leoncini, Enrico Ruffini, Paolo Fontana, Maurizio Infante, Gian Luca Pariscenti, Monica Casiraghi, Federico Rea, Extrapleural Pneumonectomy for Malignant Mesothelioma: An Italian Multicenter Retrospective Study The Annals of Thoracic Surgery. ,vol. 97, pp. 1859- 1865 ,(2014) , 10.1016/J.ATHORACSUR.2014.01.050
Emanuela Taioli, Andrea S. Wolf, Raja M. Flores, Meta-Analysis of Survival After Pleurectomy Decortication Versus Extrapleural Pneumonectomy in Mesothelioma The Annals of Thoracic Surgery. ,vol. 99, pp. 472- 480 ,(2015) , 10.1016/J.ATHORACSUR.2014.09.056
A Linton, N Pavlakis, R O'Connell, M Soeberg, S Kao, S Clarke, J Vardy, N van Zandwijk, Factors associated with survival in a large series of patients with malignant pleural mesothelioma in New South Wales. British Journal of Cancer. ,vol. 111, pp. 1860- 1869 ,(2014) , 10.1038/BJC.2014.478
Alessandra Bearz, Renato Talamini, Gilda Rossoni, Antonio Santo, Vincenzo de Pangher, Gianpiero Fasola, Francesco Rosetti, Adolfo Favaretto, Vanesa Gregorc, Massimiliano Berretta, Sandra Santarossa, Eleonora Berto, Umberto Tirelli, Re-challenge with pemetrexed in advanced mesothelioma: a multi-institutional experience. BMC Research Notes. ,vol. 5, pp. 482- 482 ,(2012) , 10.1186/1756-0500-5-482
Åslaug Helland, Steinar Solberg, Odd Terje Brustugun, Incidence and Survival of Malignant Pleural Mesothelioma in Norway: A Population-Based Study of 1686 Cases Journal of Thoracic Oncology. ,vol. 7, pp. 1858- 1861 ,(2012) , 10.1097/JTO.0B013E318275B346
Christopher Cao, David Tian, John Park, James Allan, Kristopher A. Pataky, Tristan D. Yan, A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma Lung Cancer. ,vol. 83, pp. 240- 245 ,(2014) , 10.1016/J.LUNGCAN.2013.11.026