Multiple Sclerosis and Microbes

摘要: Multiple sclerosis [MS] is the second commonest cause of chronic neurological disability after traumatic injuries. There marked geographical difference in incidence between countries temperate and tropical or subtropical regions world. Although this has been attributed to sun exposure differences prevalence vitamin D deficiency, may be related microbial exposure. The pathogenic mechanism MS complex involves multiple genetic environmental factors. an immune-related demyelinating disease brain spinal cord, but inciting agent unknown. Many naturally occurring diseases nervous system animals humans are viral origin. hygiene hypothesis burden early life suggested factor responsible for increased disorders, such as asthma affluent zones. strongest evidence favor a role microbes pathogenesis infection with Epstein–Barr virus at critical age [adolescence adulthood] genetically predisposed person, which occurs >60 % population developed compared <10 warmer developing countries. This chapter also discusses implicating other human herpes virus-6 endogenous retroviruses.