Association of MTHFR and PPARγ2 gene polymorphisms in relation to type 2 diabetes mellitus cases among north Indian population.

摘要: Abstract Background Type 2 diabetes mellitus is a multifactorial and polygenic disease, which considered as major life threatening problem all over the world. There has been worldwide effort in identification of susceptibility genes for type its complications. At present, adequate data not available dealing with MTHFR (rs1801133) PPARγ2 (rs1801282) gene polymorphisms association cases among north Indian populations. Thus, we conceived need further studies to investigate their population. Materials methods In this study, total 175 subjects including 87 88 controls were enrolled. evaluated by polymerase chain reaction restriction fragment length polymorphism (PCR–RFLP). Results The CC, CT, TT genotype frequencies obtained 40%, 43%, 17% 56%, 29%, 15% healthy respectively. OR CC was 0.54 (95%CI 0.29–0.98, P = 0.041, χ2 = 4.18, power = 0.98), CT 1.76 0.94–3.30, P = 0.07, χ2 = 3.2, power = 0.96), 1.2 0.53–2.70, P = 0.66, χ2 = 0.198, power = 0.76). GG CG, 28%, 41%, 31% 39%, 21% 0.58 0.30–1.09, P = 0.08, χ2 = 2.9, CG 1.12 0.61–2.05, P = 0.71, χ2 = 0.137, power = 0.778), 1.63 0.82–3.23, P = 0.156, χ2 = 2.01, power = 0.92). Conclusion It might be recommended that seems good marker early population at risk mellitus. While have detected significant difference allelic C (Proline) G (Alanine), but genotypic level case–control study. Further study larger groups may required validate