DNA damage induced nucleotide excision repair in Saccharomyces cerevisiae
作者： Rakesh Kumar Singh , Malini Krishna
DOI: 10.1007/S11010-006-9173-Z
关键词:
摘要: Nucleotide excision repair (NER) is the most versatile and universal pathway of DNA that capable repairing virtually any damages other than a double strand break (DSB). This has been shown to be inducible in several systems. However, question threshold nature damage can signal induction this remain poorly understood. In study it prior exposure very low doses osmium tetroxide enhanced survival wild type Saccharomyces cerevisiae when cells were challenged with UV light. Moreover, was also found treated rad3 mutants did not show indicating an involvement nucleotide survival. To probe further actual removal pyrimidine dimers by control studied. Osmium removed more efficiently as compared cells. confirmed measuring vitro synthesis cell free extracts prepared from primed It uptake active 32P significantly higher plasmid substrates incubated dependent on de novo proteins cycloheximide treatment abrogated response. The induced essentially error free.
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