Factors that influence exhaled nitric oxide in Italian schoolchildren
作者： Fabio Cibella , Giuseppina Cuttitta , Stefania La Grutta , Giovanni Passalacqua , Giovanni Viegi
DOI: 10.1016/S1081-1206(10)60318-3
关键词:
摘要: Background Conflicting results exist about the meaning of exhaled nitric oxide (eNO) in epidemiologic studies, mainly because numerous factors that may affect measurement. Objectives To evaluate role influence eNO levels a sample schoolchildren with or without respiratory diseases. We studied 335 schoolchildren, ages 10 to 16 years, from 8 schools Palermo, Italy. After questionnaire was completed, spirometry, skin tests, and measurements were performed. Results Among children, 13.7% reported symptoms bronchial asthma, 46.9% rhinitis, 39.4% asymptomatic. The ratio forced expiratory volume 1 second vital capacity 87.6% (SD, 6.4%) asthma group, 90.6% 5.0%) rhinitis 90.4% 5.1%) asymptomatic group ( P Dermatophagoides . Median 12.6 ppb nonatopic children 21.2 atopic U test). had significantly higher than did Conclusions Atopy (in particular, sensitization indoor perennial allergens) is strongly associated levels. Such association enhanced by asthma.
elsevier.com
sci-hub.se 参考文章(23)
J.F. Hunt, N. Kissoon, G.L. Piacentini, F. Ratjen, P. Silkoff, S. Stick, Members of the Task Force:, E. Baraldi, J.C. de Jongste, B. Gaston, K. Alving, P.J. Barnes, H. Bisgaard, A. Bush, C. Gaultier, H. Grasemann, Measurement of exhaled nitric oxide in children, 2001: E. Baraldi and J.C. de Jongste on behalf of the Task Force European Respiratory Journal. ,vol. 20, pp. 223- 237 ,(2002) , 10.1183/09031936.02.00293102
JD Leuppi, SH Downs, SR Downie, GB Marks, CM Salome, Exhaled nitric oxide levels in atopic children: relation to specific allergic sensitisation, AHR, and respiratory symptoms Thorax. ,vol. 57, pp. 518- 523 ,(2002) , 10.1136/THORAX.57.6.518
TIMOTHY L. FRANK, ANIL ADISESH, ANTHONY C. PICKERING, JOHN F. J. MORRISON, TAMSIN WRIGHT, HELEN FRANCIS, ANGELA FLETCHER, PETER I. FRANK, PHILIP HANNAFORD, Relationship between Exhaled Nitric Oxide and Childhood Asthma American Journal of Respiratory and Critical Care Medicine. ,vol. 158, pp. 1032- 1036 ,(1998) , 10.1164/AJRCCM.158.4.9707143
Latzin Philipp, Beck Julia, Griese Matthias, Exhaled nitric oxide in healthy children: Variability and a lack of correlation with atopy Pediatric Allergy and Immunology. ,vol. 13, pp. 37- 46 ,(2002) , 10.1034/J.1399-3038.2002.00066.X
Horváth, Barnes, Exhaled monoxides in asymptomatic atopic subjects. Clinical & Experimental Allergy. ,vol. 29, pp. 1276- 1280 ,(1999) , 10.1046/J.1365-2222.1999.00661.X
Anjani Prasad, Beverly Langford, John R. Stradling, Ling-Pei Ho, Exhaled nitric oxide as a screening tool for asthma in school children Respiratory Medicine. ,vol. 100, pp. 167- 173 ,(2006) , 10.1016/J.RMED.2005.03.039
S. Dreborg, A. Frew, Position Paper: Allergen standardization and skin tests Allergy. ,vol. 48, pp. 49- 54 ,(1993) , 10.1111/J.1398-9995.1993.TB04756.X
Miguel J. Lanz, Donald Y. M. Leung, David R. McCormick, Ronald Harbeck, Stanley J. Szefler, Carl W. White, Comparison of exhaled nitric oxide, serum eosinophilic cationic protein, and soluble interleukin-2 receptor in exacerbations of pediatric asthma Pediatric Pulmonology. ,vol. 24, pp. 305- 311 ,(1997) , 10.1002/(SICI)1099-0496(199711)24:5<305::AID-PPUL1>3.0.CO;2-H
J. G. C. Van Amsterdam, N. A. H. Janssen, G. De Meer, P. H. Fischer, S. Nierkens, H. Van Loveren, A. Opperhuizen, P. A. Steerenberg, B. Brunekreef, The relationship between exhaled nitric oxide and allergic sensitization in a random sample of school children Clinical & Experimental Allergy. ,vol. 33, pp. 187- 191 ,(2003) , 10.1046/J.1365-2222.2003.01597.X
L.P. Malmberg, T. Petäys, T. Haahtela, T. Laatikainen, P. Jousilahti, E. Vartiainen, M.J. Mäkelä, Exhaled nitric oxide in healthy nonatopic school-age children: determinants and height-adjusted reference values. Pediatric Pulmonology. ,vol. 41, pp. 635- 642 ,(2006) , 10.1002/PPUL.20417