Prognostic value of the high-mobility group box-1 in young patients with chest pain

摘要: BACKGROUND: Atherosclerosis is accepted as an inflammatory disease. Evidence suggests that inflammation evoked by injury plays a pathogenic role in all stages of atherosclerosis. This study aimed to investigate whether the high-mobility group box-1 (HMGB1) proinflammatory cytokine/nuclear protein, which derived from both injured endothelium and activated macrophages/monocytes, could contribute progression atherosclerosis other cardiovascular diseases. METHODS: was designed case–control. A total 135 patients who referred hospital due angina pectoris had diagnosis unstable were candidates angiography recruited this study. Forty coronary artery disease confirmed considered case control consists 40 persons no plaque, 55 excluded according exclusion criteria. At first, questionnaire filled for each patient including demographic factors their medical history. Then blood sample taken assess level HMGB1. Data analyzed using SPSS, Student’s independent t-test, chi-square tests. RESULTS: The mean plasma HMGB1 27.1 ± 2.9 ng/ml, while it 19.6 1.9 ng/ml groups (P = 0.03). odds ratio plaque associated with high (> 15.03 ng/ml) levels 2.50 (95% confidence interval, 1.02-6.17, P CONCLUSION: Increased concentration may be increased risk Keywords: High-Mobility Group Box-1, Coronary Artery Diseases, Inflammation, Biomarkers