Autoimmunity to cytoskeletal protein tropomyosin. A clue to the pathogenetic mechanism for ulcerative colitis.

摘要: Autoimmunity has been emphasized in the pathogenesis of ulcerative colitis and various anticolon antibodies have described. Nevertheless, nature autoantigens elusive. Using colon-eluted IgG antibody, we earlier detected an M(r) 40,000 protein, P40, colon extract. In our study, purified P40 from human to apparent homogeneity, sequenced two peptides after proteolytic digestion, demonstrated that belongs tropomyosin family. Furthermore, blood serum 95% patients with contains are reactive tropomyosin.