Relationship of serum CEA levels to tumour size and CEA content in nude mice bearing colonic-tumour xenografts

摘要: The relationship of serum carcinoembryonic antigen (CEA) levels to tumour size and content was studied in nude mice bearing well differentiated, mucinous human colonic-tumour xenografts. Blood samples were taken from normal others xenografts, whose had been calculated vivo measurements, saline KCl extracts made a proportion these tumours. Sera tissue assayed for CEA activity by double-antibody radioimmunoassay. Extracts also the livers spleens tumour-bearing mice. All sera 78% animals values less than 11.4 ng/ml. No clear correlation found between greater ng/ml or weight, concentrations total burden. concentration those tumours tested varied 1 22 microgram/g. Our results confirm extend conclusions reached (Stragand et al., 1980) studying significance with xenograft model systems. complexity factors contributing circulating is discussed light our findings.