Emerging concepts in T follicular helper cell responses to malaria

摘要: Antibody responses to malaria and candidate vaccines are short-lived in children, leaving them susceptible repeated episodes. Because T follicular helper (TFH) cells provide critical help B generate long-lived antibody responses, they have become the focus of recent studies Plasmodium-infected mice humans. The emerging data converge on common themes, namely, that malaria-induced TH1 cytokines associated with activation (i) T-like memory TFH impaired cell function, (ii) pre-TFH acquire Th1-like features (T-bet expression, IFN-γ production), which impede their differentiation into fully functional cells, thus resulting germinal center dysfunction suboptimal responses. Deeper knowledge could illuminate strategies improve through modulating This review summarizes concepts malaria.