The Effect of Dexamethasone on the Pharmacokinetics of Triazolam

摘要: The effects of short-term use a small dose dexamethasone on the pharmacokinetics and pharmacodynamics CYP3A4 substrate, triazolam, were examined. In randomized, double-blind cross-over study with two phases, ten healthy volunteers given either 1.5 mg or placebo once day for 4 days. On 5th day, 0.5 triazolam was administered orally. Plasma concentrations measured 10 hr. Dexamethasone did not have statistically significant triazolam. mean total area under plasma concentration-time curve was, however, 19% smaller during phase than (11.4 +/- 5.7 ng ml-1 hr versus 14.1 8.8 (mean S.D.); P = 0.09). four psychomotor tests employed show differences in between phases. Although had only present study, higher doses prolonged might cause more pronounced induction CYP3A4. Further studies substrates man are needed.