Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1
作者： Anna S Lok , David F Gardiner , Eric Lawitz , Claudia Martorell , Gregory T Everson
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摘要: Background Patients with chronic hepatitis C virus (HCV) infection who have not had a response to therapy peginterferon and ribavirin may benefit from the addition of multiple direct-acting antiviral agents their treatment regimen. Methods This open-label, phase 2a study included an exploratory cohort 21 patients HCV genotype 1 previous (i.e., ≥2 log10 decline in RNA after ≥12 weeks ribavirin). We randomly assigned receive NS5A replication complex inhibitor daclatasvir (60 mg once daily) NS3 protease asunaprevir (600 twice alone (group A, 11 patients) or combination alfa-2a B, 10 for 24 weeks. The primary end point was percentage sustained virologic 12 period. Results A total 4 group (36%; 2 9 HC...
sosfegato.it 参考文章(22)
J. M. Calvo Romero, J. M. Puerto Pica, Gastric adenocarcinoma and kidney transplantation Gastroenterología y Hepatología. ,vol. 21, pp. 260- ,(1998)
F. Suzuki, K. Ikeda, J. Toyota, Y. Karino, T. Ohmura, K. Chayama, S. Takahashi, Y. Kawakami, H. Ishikawa, H. Watanabe, W. Hu, F. McPhee, E. Hughes, H. Kumada, 14 DUAL ORAL THERAPY WITH THE NS5A INHIBITOR DACLATASVIR (BMS-790052) AND NS3 PROTEASE INHIBITOR ASUNAPREVIR (BMS-650032) IN HCV GENOTYPE 1B-INFECTED NULL RESPONDERS OR INELIGIBLE/INTOLERANT TO PEGINTERFERON/RIBAVIRIN Journal of Hepatology. ,vol. 56, ,(2012) , 10.1016/S0168-8278(12)60028-2
Thierry Poynard, John McHutchison, Michael Manns, Rob P Myers, Janice Albrecht, Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa‐2b and ribavirin Hepatology. ,vol. 38, pp. 481- 492 ,(2003) , 10.1053/JHEP.2003.50319
J.-P. Bronowicki, S. Pol, P.J. Thuluvath, D. Larrey, C.T. Martorell, V.K. Rustgi, D.W. Morris, Z. Younes, M.W. Fried, M. Bourliere, C. Hezode, O. Massoud, G.A. Abrams, V. Ratziu, A. Thiry, C. Llamoso, E.A. Hughes, R.G. Hindes, 1195 BMS-650032, AN NS3 INHIBITOR, IN COMBINATION WITH PEGINTERFERON ALPHA-2A AND RIBAVIRIN IN TREATMENT-NAIVE SUBJECTS WITH GENOTYPE 1 CHRONIC HEPATITIS C INFECTION Journal of Hepatology. ,vol. 54, ,(2011) , 10.1016/S0168-8278(11)61197-5
Richard E. Nettles, Min Gao, Marc Bifano, Ellen Chung, Anna Persson, Thomas C. Marbury, Ronald Goldwater, Michael P. DeMicco, Maribel Rodriguez-Torres, Apinya Vutikullird, Ernesto Fuentes, Eric Lawitz, Juan Carlos Lopez-Talavera, Dennis M. Grasela, Multiple ascending dose study of BMS-790052, a nonstructural protein 5A replication complex inhibitor, in patients infected with hepatitis C virus genotype 1. Hepatology. ,vol. 54, pp. 1956- 1965 ,(2011) , 10.1002/HEP.24609
E. Schiff, F. Poordad, I. Jacobson, S. Flamm, B. Bacon, E. Lawitz, S. Gordon, J. McHutchison, R. Ghalib, T. Poynard, M. Sulkowski, C. Trepo, M. Rizzetto, S. Zeuzem, P. Marcellin, P. Mendez, C. Brass, J.K. Albrecht, 104 BOCEPREVIR (B) COMBINATION THERAPY IN NULL RESPONDERS (NR): RESPONSE DEPENDENT ON INTERFERON RESPONSIVENESS Journal of Hepatology. ,vol. 48, pp. S46- ,(2008) , 10.1016/S0168-8278(08)60106-3
Chun-Tao Wai, Joel K Greenson, Robert J Fontana, John D Kalbfleisch, Jorge A Marrero, Hari S Conjeevaram, Anna S-F Lok, None, A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C Hepatology. ,vol. 38, pp. 518- 526 ,(2003) , 10.1053/JHEP.2003.50346
Joseph F. Perz, Gregory L. Armstrong, Leigh A. Farrington, Yvan J.F. Hutin, Beth P. Bell, The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide Journal of Hepatology. ,vol. 45, pp. 529- 538 ,(2006) , 10.1016/J.JHEP.2006.05.013
Maria Grazia Rumi, Alessio Aghemo, Gian Maria Prati, Roberta D'Ambrosio, Maria Francesca Donato, Roberta Soffredini, Ersilio Del Ninno, Antonio Russo, Massimo Colombo, Randomized study of peginterferon-α2a plus ribavirin vs peginterferon-α2b plus ribavirin in chronic hepatitis C. Gastroenterology. ,vol. 138, pp. 108- 115 ,(2010) , 10.1053/J.GASTRO.2009.08.071
Michael W. Fried, Mitchell L. Shiffman, K. Rajender Reddy, Coleman Smith, George Marinos, Fernando L. Gonçales, Dieter Häussinger, Moises Diago, Giampiero Carosi, Daniel Dhumeaux, Antonio Craxi, Amy Lin, Joseph Hoffman, Jian Yu, Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. The New England Journal of Medicine. ,vol. 347, pp. 975- 982 ,(2002) , 10.1056/NEJMOA020047