Embryonic stem cell-based models of parkinson's disease
作者： Mark J. Tomishima , Lorenz Studer
DOI: 10.1016/B978-0-12-374028-1.00035-X
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摘要: Publisher Summary This chapter explores uses of embryonic stem cells (ESCs) aimed at modeling Parkinson's disease in vitro. ES-derived mDA neurons provide a number advantages over embryo-derived neurons. One the main is unlimited supply ES-based differentiations can be scaled up to required ESCs are pluripotent, meaning they differentiate into wide range cell types, and therefore PD-related genotype differentiated many different types develop any adult organism, such as case mouse ESCs. Genetically modified introduced developing embryo subject partial (chimera) or complete (tetraploid aggregation). Another advantage using ability precisely alter genome karotypically normal cells. An approach for genetic modification with use conventional, plasmid-based transgenes whereby promoter–gene–polyadenylation cassette randomly integrated ESC genome. ESC-based DA also an ideal substrate large-scale, high-throughput screens.
sci-hub.st 参考文章(109)
Ranjita Betarbet, Todd B. Sherer, Gillian MacKenzie, Monica Garcia-Osuna, Alexander V. Panov, J. Timothy Greenamyre, Chronic systemic pesticide exposure reproduces features of Parkinson's disease Nature Neuroscience. ,vol. 3, pp. 1301- 1306 ,(2000) , 10.1038/81834
Marten P. Smidt, Ceriel H. J. Asbreuk, Joke J. Cox, Haixu Chen, Randy L. Johnson, J. Peter H. Burbach, A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b. Nature Neuroscience. ,vol. 3, pp. 337- 341 ,(2000) , 10.1038/73902
Gunnar Schulte, Vítězslav Bryja, Nina Rawal, Goncalo Castelo-Branco, Kyle M. Sousa, Ernest Arenas, Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. Journal of Neurochemistry. ,vol. 92, pp. 1550- 1553 ,(2005) , 10.1111/J.1471-4159.2004.03022.X
Mark Zervas, Sandra Blaess, Alexandra L. Joyner, Classical Embryological Studies and Modern Genetic Analysis of Midbrain and Cerebellum Development Current Topics in Developmental Biology. ,vol. 69, pp. 101- 138 ,(2005) , 10.1016/S0070-2153(05)69005-9
Richard Wade-Martins, Edward R. Smith, Edyta Tyminski, E. Antonio Chiocca, Yoshinaga Saeki, An infectious transfer and expression system for genomic DNA loci in human and mouse cells Nature Biotechnology. ,vol. 19, pp. 1067- 1070 ,(2001) , 10.1038/NBT1101-1067
Lilla M. Farkas, Nicole Dünker, Eleni Roussa, Klaus Unsicker, Kerstin Krieglstein, Transforming growth factor-beta(s) are essential for the development of midbrain dopaminergic neurons in vitro and in vivo. The Journal of Neuroscience. ,vol. 23, pp. 5178- 5186 ,(2003) , 10.1523/JNEUROSCI.23-12-05178.2003
K.A. Adams, J.A. Golden, J.M. Maida, R.D. Riddle, The transcription factor Lmx1b maintains Wnt1 expression within the isthmic organizer Development. ,vol. 127, pp. 1857- 1867 ,(2000)
J. Y. H. Li, New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression. Development. ,vol. 132, pp. 1971- 1981 ,(2005) , 10.1242/DEV.01727
Hiroshi Sasaki, Brigid L.M. Hogan, HNF-3β as a regulator of floor plate development Cell. ,vol. 76, pp. 103- 115 ,(1994) , 10.1016/0092-8674(94)90176-7
Hiroshi Kawasaki, Kenji Mizuseki, Satomi Nishikawa, Satoshi Kaneko, Yoshihisa Kuwana, Shigetada Nakanishi, Shin-Ichi Nishikawa, Yoshiki Sasai, Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron. ,vol. 28, pp. 31- 40 ,(2000) , 10.1016/S0896-6273(00)00083-0