Overview of studies on liver carcinogenesis in English sole from Puget Sound; evidence for a xenobiotic chemical etiology II: Biochemical studies

摘要: The levels of aromatic hydrocarbons in sediments Puget Sound, Washington, are positively correlated with the prevalence hepatic neoplasms and related lesions English sole (Parophrys vetulus). To investigate biochemical processes involved chemical carcinogenesis fish from we have studied uptake, activation, detoxication polycyclic (PAHs) sole, compared these data to PAH metabolism a species, starry flounder (Platichthys stellatus), which shows lower than sole. results both laboratory field studies show that sediment-associated PAHs biologically available flatfish species accumulate similar PAHs. Analyses DNA using 32P-postlabeling technique indicate xenobiotic chemicals were adducted contaminated sites but not reference sites. Studies ability metabolize benzo(a)pyrene (BaP) bind reactive BaP intermediates differences carcinogenic may explain, at least part, apparent susceptibility chemically induced hepatocarcinogenesis.