BASIS FOR TARGETING MET ACTIVATION MEDIATED RESISTANCE TO PI3K INHIBITION IN BREAST CANCER

Bryan Hennessy, Mark Carey, Gordon B. Mills, Roshan Agarwal, PI3K pathway-directed therapeutic strategies in cancer. Current opinion in investigational drugs. ,vol. 11, pp. 615- 628 ,(2010)

Patrick C Ma, Gautam Maulik, James Christensen, Ravi Salgia, c-Met: Structure, functions and potential for therapeutic inhibition Cancer and Metastasis Reviews. ,vol. 22, pp. 309- 325 ,(2003) , 10.1023/A:1023768811842

N.A. Lokker, M.R. Mark, E.A. Luis, G.L. Bennett, K.A. Robbins, J.B. Baker, P.J. Godowski, Structure-function analysis of hepatocyte growth factor: identification of variants that lack mitogenic activity yet retain high affinity receptor binding. The EMBO Journal. ,vol. 11, pp. 2503- 2510 ,(1992) , 10.1002/J.1460-2075.1992.TB05315.X

Ana M. Gonzalez-Angulo, Huiqin Chen, Meghan S. Karuturi, Mariana Chavez-MacGregor, Spyrus Tsavachidis, Funda Meric-Bernstam, Kim-Anh Do, Gabriel N. Hortobagyi, Patricia A. Thompson, Gordon B. Mills, Melissa L. Bondy, George R. Blumenschein, Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer. Cancer. ,vol. 119, pp. 7- 15 ,(2013) , 10.1002/CNCR.27608

George Michalopoulos, Reza Zarnegar, Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes. Cancer Research. ,vol. 49, pp. 3314- 3320 ,(1989)

Saijun Fan, Ji-An Wang, Ren-Qi Yuan, Sara Rockwell, Janet Andres, Andrey Zlatapolskiy, Itzhak D Goldberg, Eliot M Rosen, Scatter factor protects epithelial and carcinoma cells against apoptosis induced by DNA-damaging agents. Oncogene. ,vol. 17, pp. 131- 141 ,(1998) , 10.1038/SJ.ONC.1201943

C.-H. Huang, D. Mandelker, O. Schmidt-Kittler, Y. Samuels, V. E. Velculescu, K. W. Kinzler, B. Vogelstein, S. B. Gabelli, L. M. Amzel, The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations Science. ,vol. 318, pp. 1744- 1748 ,(2007) , 10.1126/SCIENCE.1150799

Genichiro Edakuni, Eizaburo Sasatomi, Toshimi Satoh, Osamu Tokunaga, Kohji Miyazaki, Expression of the hepatocyte growth factor/c-Met pathway is increased at the cancer front in breast carcinoma. Pathology International. ,vol. 51, pp. 172- 178 ,(2001) , 10.1046/J.1440-1827.2001.01182.X

L G Fulford, D F Easton, J S Reis-Filho, A Sofronis, C E Gillett, S R Lakhani, A Hanby, Specific morphological features predictive for the basal phenotype in grade 3 invasive ductal carcinoma of breast. Histopathology. ,vol. 49, pp. 22- 34 ,(2006) , 10.1111/J.1365-2559.2006.02453.X

Michael Bilous, Patrick Fitzgibbons, Wedad Hanna, Robert B. Jenkins, Pamela B. Mangu, Soonmyung Paik, Edith A. Perez, Michael F. Press, Patricia A. Spears, Gail H. Vance, Giuseppe Viale, Daniel F. Hayes, Antonio C. Wolff, M. Elizabeth H. Hammond, David G. Hicks, Mitch Dowsett, Lisa M. McShane, Kimberly H. Allison, Donald C. Allred, John M.S. Bartlett, Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update. Archives of Pathology & Laboratory Medicine. ,vol. 138, pp. 241- 256 ,(2014) , 10.5858/ARPA.2013-0953-SA