Binocular suppression in the macaque lateral geniculate nucleus reveals early competitive interactions between the eyes.

摘要: The lateral geniculate nucleus (LGN) of the dorsal thalamus is primary recipient two eyes’ outputs. Most LGN neurons are monocular in that they activated by visual stimulation through only one (dominant) eye. However, there both intrinsic connections and inputs from binocular structures to could provide these with signals originating other (non-dominant) Indeed, previous work introducing luminance differences across eyes or using a single-contrast stimulus showed modulation for single unit activity anesthetized macaques multiunit awake macaques. Here, we sought determine influence contrast viewed non-dominant dominant on single-unit responses To do this, adjusted each eye’s signal strength independently varying stimuli presented eyes. Specifically, recorded spiking while drifting gratings contrast. We found all types (parvo-, magno-, koniocellular) were significantly suppressed when at low eye high Further, antagonistic interaction, whereby magnitude suppression diminished eye, These results suggest represents site pre-cortical processing involved resolving discrepant between Significance A fundamental feature primate system its arrangement, which affords stereovision hyperacuity. consequence this arrangement views need be resolved yield singular vision, normally accomplished fusion inputs. This has been shown occur cortex, subsequent thalamic processing. show receiving excitatory retinal input can high-contrast indicating serves as