Seasonal variations in vitamin D levels in melanoma patients: a single-centre prospective pilot comparative study

摘要: Background  More than 90% of vitamin D synthesis is dependent on UV exposure. Photosensitive disorders such as lupus erythematosus, protoporphyria and xeroderma require strict sun avoidance, deficiency has been demonstrated in these patients. Melanoma patients are also instructed to avoid exposure may hence be expected deficient. Materials methods  Winter summer levels were compared a group melanoma (n = 61) age- phototype-matched controls (n = 53) without photosensitive disorders. Results  Oral supplementary intake was reported 32.7% the 15.1% control group. Despite oral supplementation, only 25% presented with 30 ng/mL or higher. In non-supplemented subjects groups, respectively, mean winter below recommended threshold at 12.6 ng/mL vs. 13.2 ng/mL, but not statistically different. These values increased significantly both groups during 24.6 23.8 ng/mL respectively. Conclusion  Unexpected, significant increases seen summer, suggesting non-adherence photoprotective measures reflecting heliophilic behaviour. Vitamin supplementation summer.