Mild Cognitive Impairment Is Early-Stage Alzheimer Disease: Time to Revise Diagnostic Criteria

D. S. Knopman, J. E. Parisi, A. Salviati, M. Floriach-Robert, B. F. Boeve, R. J. Ivnik, G. E. Smith, D. W. Dickson, K. A. Johnson, L. E. Petersen, W. C. McDonald, H. Braak, R. C. Petersen, Neuropathology of cognitively normal elderly. Journal of Neuropathology and Experimental Neurology. ,vol. 62, pp. 1087- 1095 ,(2003) , 10.1093/JNEN/62.11.1087

Joseph L. Price, John C. Morris, Tangles and plaques in nondemented aging and “preclinical” Alzheimer's disease Annals of Neurology. ,vol. 45, pp. 358- 368 ,(1999) , 10.1002/1531-8249(199903)45:3<358::AID-ANA12>3.0.CO;2-X

H.R. Griffith, K. Belue, A. Sicola, S. Krzywanski, E. Zamrini, L. Harrell, D.C. Marson, Impaired financial abilities in mild cognitive impairment: a direct assessment approach. Neurology. ,vol. 60, pp. 449- 457 ,(2003) , 10.1212/WNL.60.3.449

William R. Markesbery, Frederick A. Schmitt, Richard J. Kryscio, Daron G. Davis, Charles D. Smith, David R. Wekstein, Neuropathologic substrate of mild cognitive impairment. JAMA Neurology. ,vol. 63, pp. 38- 46 ,(2006) , 10.1001/ARCHNEUR.63.1.38

P. Tiraboschi, L. A. Hansen, L. J. Thal, J. Corey-Bloom, The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology. ,vol. 62, pp. 1984- 1989 ,(2004) , 10.1212/01.WNL.0000129697.01779.0A

M. Storandt, E. A. Grant, J. P. Miller, J. C. Morris, Rates of progression in mild cognitive impairment and early Alzheimer's disease. Neurology. ,vol. 59, pp. 1034- 1041 ,(2002) , 10.1212/WNL.59.7.1034

Ronald C Petersen, Ronald G Thomas, Michael Grundman, David Bennett, Rachelle Doody, Steven Ferris, Douglas Galasko, Shelia Jin, Jeffrey Kaye, Allan Levey, Eric Pfeiffer, Mary Sano, Christopher H Van Dyck, Leon J Thal, None, Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment The New England Journal of Medicine. ,vol. 352, pp. 2379- 2388 ,(2005) , 10.1056/NEJMOA050151

Michael Grundman, Ronald C Petersen, Steven H Ferris, Ronald G Thomas, Paul S Aisen, David A Bennett, Norman L Foster, Clifford R Jack Jr, Douglas R Galasko, Rachelle Doody, Jeffrey Kaye, Mary Sano, Richard Mohs, Serge Gauthier, Hyun T Kim, Shelia Jin, Arlan N Schultz, Kimberly Schafer, Ruth Mulnard, Christopher H Van Dyck, Jacobo Mintzer, Edward Y Zamrini, Deborah Cahn-Weiner, Leon J Thal, None, Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials. JAMA Neurology. ,vol. 61, pp. 59- 66 ,(2004) , 10.1001/ARCHNEUR.61.1.59

John C. Morris, Martha Storandt, J. Phillip Miller, Daniel W. McKeel, Joseph L. Price, Eugene H. Rubin, Leonard Berg, Mild cognitive impairment represents early-stage Alzheimer disease. JAMA Neurology. ,vol. 58, pp. 397- 405 ,(2001) , 10.1001/ARCHNEUR.58.3.397

Thomas W. Mitchell, Elliott J. Mufson, Julie A. Schneider, Elizabeth J. Cochran, Jonathan Nissanov, Li-Ying Han, Julia L. Bienias, Virginia M.-Y. Lee, John Q. Trojanowski, David A. Bennett, Steven E. Arnold, Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Annals of Neurology. ,vol. 51, pp. 182- 189 ,(2002) , 10.1002/ANA.10086