PIK3CA Mutations Are Associated With Decreased Benefit to Neoadjuvant Human Epidermal Growth Factor Receptor 2–Targeted Therapies in Breast Cancer

作者: Ian J. Majewski , Paolo Nuciforo , Lorenza Mittempergher , Astrid J. Bosma , Holger Eidtmann

DOI: 10.1200/JCO.2014.55.2158

关键词:

摘要: Purpose We investigated whether mutations in the gene encoding phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) correlates with response to neoadjuvant human epidermal growth factor receptor 2 (HER2) –targeted therapies patients breast cancer.

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