Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease
作者： E. D. London , S. B. Waller
DOI: 10.1007/978-1-4684-5194-8_19
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摘要: The literature concerning age effects on cholinergic neurochemical parameters, in the brain presents a heterogeneous picture, both within and among species. Whereas some studies of human postmortem material have demonstrated age-dependent declines choline acetyltransferase (ChAT) activity various regions (5, 12, 19), others revealed no ChAT losses same 10, 19, 28). In from C57BL/6J A/J mice, we observed increases (26); whereas, other changes or decreases brains mice (23, 25), mouse strains (24), rats (2, 23, 25).
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