KLRB Receptor Family and Human Early Activation Antigen (CD69)

摘要: Natural killer cells are important component of the innate immune system, providing protection against intracellular infection particularly viruses and also neoplasia through direct cytotoxic mechanisms secretion cytokines. They mediate their effects cytolysis, release cytokines regulation subsequent adaptive responses. called ‘natural’ killers because, unlike T cells, they do not require a previous challenge preactivation to become active. NK can be activated by range soluble factors, including type I interferons, IL-2, IL-12, IL-15 IL-18, but cell contact between receptors target ligands. possess an elaborate array receptors, which regulate secretory functions upon interaction with MHC class proteins. Determination structures ligand complexes has led fast growth in our understanding activation recognition these as well function immunity. B significantly differentially influence homeostasis phenotype cells. The is tightly regulated fine balance inhibitory activating signals that delivered diverse surface receptors. A prerequisite for attack presence on ligands low level or absence It was believed self-tolerance achieved expression each at least one self-MHC specific receptor. However, this dogma been challenged after identification population normal mice lack molecules (Kumar McNerney 2005; Fernandez et al. 2005). Therefore, it made clear some additional contribute modulation characterization physiological allow us comprehensive function.