Autoimmunity versus Autoinflammation - Friend or Foe?

摘要: Autoimmunity" is a designation dependent on the conventional immunological issue of self/non- self discrimination. Identification novel target auto- antigens still an important ongoing in classical tissue-specific autoimmune bullous diseases and immune connective tissue diseases. In contrast, synchro- nized with paradigm shift fundamental aspect immunity to danger sensing/signaling, distinct colla- gen-like have been defined by genetic muta- tions causing dysregulated innate immunity/inflamma- tion designated as "autoinflammatory" Due clinical etiological similarities, concept autoinflammatory has expanded include non-hereditary collagen-like diseases, tissue- specific chronic idiopathic inflammatory metabolic On other hand, various causes identified border these two pathophysiologies becoming obscure. Instead, variable mixture both autoimmu- nity autoinflammation can cause each phenotype level antigen specificity.