Turbidimetric measurement and prediction of dissolution rates of poorly soluble drug nanocrystals.

摘要: Rapid dissolution rates of nanocrystal suspensions the poorly water-soluble drugs, danazol and itraconazole were measured continuously by in-situ turbidimetry. For pre-wetted 300 nm particles, half-lives as short a few seconds determined upon adding surfactant to initiate dissolution. A mass transfer model is presented determine particle size distribution rate in terms two steps: interfacial reaction, consisting micelle uptake desorption, followed diffusion drug-loaded micelles. The reaction constant, k(S), regressed from turbidity versus time data, conjunction with Mie theory light scattering, was independent size. Therefore, data for micron-sized drug which are widely available, may be used predict behavior submicron sizes down 100 nm. micellar solubility k(S) significantly smaller than danazol, consistent itraconazole's larger molecular particles 1 mum, resistance dominant. Since this has received little attention previous studies, further emphasis on design nanoparticles more rapid offers possibility improvements rates.