An unexpected paradox: wall shear stress in the aorta is less in patients with severe atherosclerosis regardless of obesity.

摘要: Abstract Background Obesity is a widespread condition that more prevalent in Western countries compared to others. Aortic atherosclerosis (AA) frequently has been associated with obesity. An obesity paradox, where morbidly obese decedents had either no or minimal AA nonobese decedents, recently described by some of us. The explanation for this almost counterintuitive paradox yet be determined, but number hypotheses were advanced, including hemodynamic factors producing aortic wall shear stress (WSS). purpose the present study was determine if there relationship between and WSS, as determined postmortem measurement diameters. Methods Circumferences aorta at levels ascending, thoracic abdominal measured 274 consecutive autopsies over 2-year period time. assessed using previously grading scale mild severe. mathematically converted diameters WSS calculated Hagen-Poiseuille formula. Two different methods estimate cardiac output used, both based on literature methods, one which body mass index (BMI) dependent, other BMI independent. Univariate multivariable analyses age, BMI, gender, race severity performed. Results Of 140 134 moderate severe AA. Conclusions Our data demonstrate unexpectedly lower those This observation, requires further investigations, seen all ranges confirmed 2 calculate WSS.