STRUCTURAL DISORDER AND PROTEIN ELASTICITY

摘要: An emerging class of disordered proteins underlies the elasticity many biological tissues. Elastomeric are essential to function machinery as diverse human arterial wall, capture spiral spider webs and jumping mechanism fleas. In this chapter, we review what is known about molecular basis functional role structural disorder in protein elasticity. general, elastic recoil due a combination internal energy entropy. rubber-like elastomeric proteins, dominant driving force increased entropy relaxed state relative stretched state. Aggregates these intrinsically or fuzzy, with high polypeptide chain We focus our discussion on sequence, structure five elastin, resilin, silk, abductin ColP. Although group elastomers together into one they exhibit broad range sequence motifs, mechanical properties functions. Understanding how modulates both will help advance rational design biomaterials such artificial skin vascular grafts.