GABAA receptor overexpression in the lateral hypothalamic area attenuates gastric ischemia‑reperfusion injury in rats
作者： LIN GAO , TAO ZHU , GUILIN XIE , XIANGXIN LOU , SHIBAO LI
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摘要: Abstract Excessive activation of the greater splanchnic nerve (GSN) has previously been determined to contribute progression gastric ischemia‑reperfusion (GI‑R) injury. The present study was designed estimate protective effects GABAA receptor (GABA(A)R) overexpression in lateral hypothalamic area (LHA) against GI‑R injury model induced rats by clamping celiac artery for 30 min and then reperfusing 1 h. Microinjection recombinant adenoviral vectors overexpressing GABA(A)R (Ad‑GABA(A)R) or control (Ad‑Con) into LHA conducted normal rats. Significant were observed on day 2 after Ad‑GABA(A)R treatment reduced plasma norepinephrine levels, angiotensin II levels peripheral GSN activity, but increased mucosal blood flow, as compared with Ad‑Con treatment. These results indicate that vector‑induced blunts activity subsequently alleviates
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