Pulp Innate Immune Defense: Translational Opportunities.

摘要: Abstract Introduction The improvement of regenerative endodontic procedures requires an understanding the key clinical questions combined with a fundamental biological knowledge how dental tissues behave during health, disease, and repair. Therefore, partnerships between clinicians basic scientists are essential to drive field forward improve patient outcomes. Methods This review aimed provide background dentin-pulp biology interaction infection, inflammation, regeneration. Results We have highlighted release neutrophil extracellular traps (NETs) within pulp double-edged; while they aim limit bacterial may actually exacerbate cell death chronic inflammation. Aberrant levels these structures occur because ineffective host immunologic processes, viral infections, or impaired clearance caused by virulence factors. also postulate proinflammatory link in NETs inflammasome activated pathogen-associated molecular patterns damage-associated patterns. Subsequently, we discuss areas potentially fruitful for future exploitation involving NET inhibitors, modulators, phototherapies, novel epigenetic approaches. Conclusions Sustained scientist-clinician research along increased association inflammation regeneration complex will lead benefit.