Hepatitis Flares Are Associated With Better Outcomes Than No Flare in Patients With Decompensated Cirrhosis and Chronic Hepatitis B Virus Infection

摘要: Background & Aims Little is known about the effects of baseline hepatitis flares (level alanine aminotransferase ≥5-fold above upper limit normal) on outcomes patients with chronic B virus (HBV) infection decompensated cirrhosis treated nucleos(t)ide analogues. We aimed to investigate these effects. Methods performed a cohort study 511 consecutive (78.1% men; 58.7% at baseline) HBV and who were analogues as soon decompensation was noted. Patients enrolled from January 2002 March 2018 tertiary care center in Taiwan followed up for 16 years. Results had higher mean levels DNA (6.44 ± 1.52 vs 6.08 ± 1.46 log10 IU/mL; P = .003), surface antigen, total bilirubin; prolonged prothrombin time; platelet counts (108.0 42.9 83.6 ± 44.7 103/μL; Conclusions In 16-year analogues, flare associated independently better long-term (≥3 mo) than no flare.