Selective transcriptional regulations in the human liver cell by hepatitis B viral X protein.
作者： Jaeseok Han , Hae Yong Yoo , Byung Hyune Choi , Hyune Mo Rho
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摘要: Abstract The hepatitis B viral X protein (HBx) is known as a transcription factor and potential oncogene. To gain better view of the effect HBx on transcriptional regulation in human liver cell, we constructed HepG2 cell line stably expressing (HepG2-HBx), performed cDNA microarray analysis 588 cellular cDNAs comparing with untransformed control cells. Two genes (IGFR-2, RhoA) oncogenes, one gene (p55CDC) cycle regulators, three (thrombin receptor, MLK-3, MacMARCKS) intracellular transducers, (HSP27) stress response proteins, two (FAST kinase, Bak) apoptosis (p21 WAF ) factors were highly up-regulated; (transcription elongation SII) (monocyte chemotactic 1, T-lymphocyte-secreted I-309) growth down-regulated. These results showed selective by cell.
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