Metformin: Risk-benefit profile with a focus on cancer

摘要: Introduction: Epidemiological evidence suggests an increased incidence of cancer in obese, prediabetic, and diabetic patients a reduced risk mortality on metformin compared with other antidiabetic drugs. In vitro studies support the efficacy therapy prevention. Although seems to be promising as chemopreventive or therapeutic drug, principal consideration is whether will effective clinical trials for nondiabetic subjects only diabetics insulin resistance. Safety even more important treating patients.Areas covered: The present review focuses epidemiological data testing cancer, safety future development this drug.Expert opinion: Meta-analyses which treatment has been used show pos...