Gene therapy for cell proliferative diseases
作者： Alan Linn Murphree , Yuen Kai Fung
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摘要: The present invention provides a method for the treatment of inappropriate or pathological cell growth such as exists in cancer, malignant proliferation, benign proliferative diseases and other diseases. also treating cell-proliferative individuals comprising administration one more active gene copies negatively-acting regulatory (NGR) element to an abnormally proliferating cell. In another embodiment inhibit abnormal proliferation by inserting into cell, synthetic DNA RNA construct which inactivates functional expression PGR element.
lens.org 参考文章(13)
Kevin J. Scanlon, Ribozyme mediated reversal of transformation by cleavage of the hras oncogene rna ,(1990)
David W. Yandell, Thaddeus P. Dryja, Stephen Friend, Diagnosis of retinoblastoma ,(1989)
M. Cotten, M.L. Birnstiel, Ribozyme mediated destruction of RNA in vivo. The EMBO Journal. ,vol. 8, pp. 3861- 3866 ,(1989) , 10.1002/J.1460-2075.1989.TB08564.X
Donald Joseph Kessler, Michael Edward Hogan, Method for making synthetic oligonucleotides which bind specifically to target sites on duplex dna molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use ,(1989)
Robert A. Weinberg, David F. Stern, Cornelia I. Bargmann, Methods and artificial genes for antagonizing the function of an oncogene ,(1984)
Wen-Hwa Lee, Phang-Lang Chen, Genetic mechanisms of tumor suppression ,(1991)
Jim Haseloff, Wayne L. Gerlach, Simple RNA enzymes with new and highly specific endoribonuclease activities Nature. ,vol. 334, pp. 585- 591 ,(1988) , 10.1038/334585A0
Mark E. Ewen, Yigong Xing, Jeanne Bentley Lawrence, David M. Livingston, Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell. ,vol. 66, pp. 1155- 1164 ,(1991) , 10.1016/0092-8674(91)90038-Z
F. H. Cameron, P. A. Jennings, Specific gene suppression by engineered ribozymes in monkey cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 86, pp. 9139- 9143 ,(1989) , 10.1073/PNAS.86.23.9139
R Bookstein, J. Shew, P. Chen, P Scully, W. Lee, Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene Science. ,vol. 247, pp. 712- 715 ,(1990) , 10.1126/SCIENCE.2300823