Fyn mediates transforming growth factor-beta1-induced down-regulation of E-cadherin in human A549 lung cancer cells.
作者： An Na Kim , Woo-Kwang Jeon , Kyu-Hyoung Lim , Hui-Young Lee , Woo Jin Kim
DOI: 10.1016/J.BBRC.2011.02.134
关键词:
摘要: Transforming growth factor-beta (TGF-β) signaling positively contributes to the regulation of tumor metastasis. However, underlying molecular mechanisms are less well defined. We here show that Fyn, a member Src family tyrosine kinases, plays critical role in mediating TGF-β1-induced down-regulation E-cadherin human A549 lung cancer cells. Blockade Fyn with siRNA knockdown or ligand-binding defective mutant significantly lowered ability TGF-β1 repress expression. Furthermore, our results demonstrated facilitates TGF-β1-mediated suppression through p38 kinase-dependent induction Snail. Collectively, findings identify Fyn-p38-Snail cascade as new pathway oncogenic TGF-β function.
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