Bone Morphogenetic Protein Receptor Type II C-Terminus Interacts with c-Src: Implication for a Role in Pulmonary Arterial Hypertension

摘要: Mutations of bone morphogenetic protein receptor type II (BMPR-II) have been associated with familial and idiopathic pulmonary arterial hypertension (PAH). BMPR-II is a member the transforming growth factor-β superfamily. It consists extracellular, transmembrane, kinase domains, unique C-terminus mostly unknown function. However, number PAH-causing mutations are predicted to truncate C-terminus, suggesting that this domain plays an important role in homeostasis vessels. In study, we sought elucidate functional by seeking its interacting partners. Using yeast two-hybrid screening, identified c-Src tyrosine as binding partner C-terminus. vitro co-immunoprecipitation confirmed their interaction. truncating disrupted interaction, while missense mutation within reduced addition, colocalized ...