Acute demyelination in children: predicting pediatric multiple sclerosis manifestation

摘要: Evaluation of: Banwell B, Bar-Or A, Arnold DL et al. Clinical, environmental, and genetic determinants of multiple sclerosis in children with acute demyelination: a prospective national cohort study. Lancet Neurol. 10(5), 436–445 (2011). This study represents Canadian investigating risk (MS) development presenting an demyelination event. Out 302 followed for median 3.14 years, 63 (21%) were diagnosed MS during this period time. HLA-DRB1*15 alleles, remote Epstein–Barr virus infection reduced vitamin D levels each independently associated increased but did not show interacting effects. Based on MRI findings, age onset clinical presentation, the authors developed decision tree, suggesting highest T2 lesions baseline that >11.85 years at (60.6%). While seems helpful preliminary tool clinicians, longer follow-up time as w...