Growth Factor Upregulation during Obliterative Bronchiolitis in the Mouse Model
作者： Robert M. Aris , Sean Walsh , Worakij Chalermskulrat , Vasantha Hathwar , Isabel P. Neuringer
DOI: 10.1164/RCCM.2102106
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摘要: Obliterative bronchiolitis (OB), or chronic allograft rejection, is a major cause of morbidity and mortality after lung transplantation. The goal these experiments was to determine whether several important growth factors were upregulated during OB in the mouse heterotopic trachea model. Isografts (BALB/c into BALB/c) allografts C57BL/6) implanted three sets cyclosporine-treated animals harvested from 2 10 weeks. Ribonucleic acid isolated using cesium chloride-guanidine method reverse transcribed semiquantitated with polymerase chain reaction specific primers for platelet-derived factor (PDGF)-A PDGF-B chains, fibroblast (FGF) isoforms 1 2, transforming factor-β, tumor necrosis factor-α (TNF-α), edothelin-1, (prepro) epidermal factor, insulin-like factor-1, β-actin as control. Transforming TNF-α, endothelin-1, factor-1 expression inc...
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