Recyclization of 2-iminocoumarin-3-carbonitriles with 2-aminothiobenzamide: a new synthetic route to substituted 2-(2-iminocoumarin-3-yl)quinazoline-4(3H)-thiones

作者: Pavlo E Shynkarenko , Sergiy V Vlasov , Sergiy M Kovalenko , Valentin P Chernykh , None

DOI: 10.1080/17415993.2010.509506

关键词:

摘要: The reaction of 2-aminothiobenzamide with either 2-iminocoumarin-3-carbonitrile or 2-iminocoumarin-3-thiocarboxamides has been studied. It established that in both cases, 2-(2-iminocoumarin-3-yl)quinazoline-4(3H)-thiones are formed as the result a two-step procedure. reactions arylamines and alkylating agents have

参考文章(34)
Elke Bergmann-Leitner, Editorial [Hot Topic: Anti-Cancer Drugs Executive Editor: Elke Bergmann-Leitner] Current Pharmaceutical Design. ,vol. 15, pp. 730- 731 ,(2005) , 10.2174/138161208784246207
S. Jantová, G. Greif, K. Špirková, Š. Stankovský, M. Oravcová, Antibacterial effects of trisubstituted quinazoline derivatives. Folia Microbiologica. ,vol. 45, pp. 133- 137 ,(2000) , 10.1007/BF02817411
Wolfgang Walter, Jürgen Voß, Über die Oxydationsprodukte von Thiocarbonsäureamiden, XIII. Oxydationsreaktionen an Chinazolinthionen‐(4) European Journal of Organic Chemistry. ,vol. 695, pp. 87- 97 ,(1966) , 10.1002/JLAC.19666950111
H. Turki, S. Abid, Y. Le Bigot, S. Fery‐Forgues, R. El Gharbi, Novel Synthesis of 2‐Oxo‐2H‐Benzopyrano[2,3‐d]Pyrimidines Synthetic Communications. ,vol. 34, pp. 3553- 3563 ,(2004) , 10.1081/SCC-200031013
Igor E Bylov, Maksym V Vasylyev, Yaroslav V Bilokin, Synthesis and anti-inflammatory activity of N-substituted 2-oxo-2H-1-benzopyran-3-carboxamides and their 2-iminoanalogues. European Journal of Medicinal Chemistry. ,vol. 34, pp. 997- 1001 ,(1999) , 10.1016/S0223-5234(99)00119-1
Jiří Hanusek, Ludmila Hejtmánková, Lenka Kubicová, Miloš Sedlák, Synthesis of Substituted 2-Benzoylaminothiobenzamides and Their Ring Closure to Substituted 2-Phenylquinazoline-4-thiones Molecules. ,vol. 6, pp. 323- 337 ,(2001) , 10.3390/60400323
Chi-Kuang Huang, Feng-Ying Wu, You-Xi Ai, POLYHYDROXYLATED 3-(N-PHENYL) CARBAMOYL-2-IMINOCHROMENE DERIVATIVES AS POTENT INHIBITORS OF TYROSINE KINASE P60C-SRC Bioorganic & Medicinal Chemistry Letters. ,vol. 5, pp. 2423- 2428 ,(1995) , 10.1016/0960-894X(95)00422-P
John A Hadfield, Vasilios H Pavlidis, Philip J Perry, Alan T McGown, Synthesis and anticancer activities of 4-oxobenzopyrano[2,3-d]pyrimidines. Anti-Cancer Drugs. ,vol. 10, pp. 591- 595 ,(1999) , 10.1097/00001813-199907000-00011
P. Molina, A. Arques, Ma. L. Garcia, Ma. V. Vinader, Reaction of 4-Methylthioquinazoline-3-Oxides with Active Methylene Compounds: Synthesis of the Novel Isoxazolo[2,3-c]Quinazoline Ring System Synthetic Communications. ,vol. 17, pp. 1449- 1457 ,(1987) , 10.1080/00397918708057771