Effect of iodinated contrast media on the oxygen tension in the renal cortico-medullary region of pigs

摘要: Repeated injections of iodinated contrast media (CM) can lead to a deterioration the renal blood flow, redistribute from cortex other parts kidney and cause small decreases flow in cortical capillaries, significant reduction peritubular capillaries vasa recta. Therefore, study pigs was designed, show whether repeated injection CM boli, alone, oxygenation cortico-medullar tissue - region with highest oxygen demand pigs.While mean pO2-value had only decreased by 0.3 mmHg 29.9±4.3 29.6±4.3 (p = 0.8799) after tenth Iodixanol bolus, it 5.9 34.0±4.3 28.1±4.3 Iopromide bolus (p = 0.044). This revealed remarkable difference influence these on partial pressure kidney.Repeated applications pressure. In line earlier studies showing redistribution areas, this that induced no changes pO2 which confirms did not hinder through micro-vessels. These results are favor hypothesis Brezis microcirculatory disorder might be basis for development CI-AKI.