Radioimmunotherapy of solid tumors targeting a cell-surface protein, FZD10: therapeutic efficacy largely depends on radiosensitivity
作者： Hirofumi Hanaoka , Toyomasa Katagiri , Chikako Fukukawa , Hiroki Yoshioka , Shinji Yamamoto
DOI: 10.1007/S12149-009-0265-1
关键词:
摘要: Objective Frizzled homolog 10 (FZD10) is expressed at high levels on the cell surface of almost all synovial sarcoma tissues, but absent in most normal organs. In a previous study, yttrium-90 (90Y)-labeled anti-FZD10 antibody (MAb 92-13) showed considerable therapeutic efficacy cell-bearing mice. The purpose present study was to elucidate factors associated with this 90Y-MAb 92-13.
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