Uptake, Metabolism and Biological Effect of the Olive Oil Phenol Hydroxytyrosol in Human HepG2 Cells

摘要: Publisher Summary Extensive uptake and metabolism of the olive oil phenolic hydroxytyrosol was observed using HepG2 cells as a model system human liver. The main metabolites were glucuronides, methylglucuronides methyl conjugates, in agreement with data from studies where methylated glucuronidated only conjugates plasma urine samples. antioxidant effect cultured liver extends protective reported for other dietary bioactive compounds to one most common them Mediterranean diet. Hydroxytyrosol may prepare defense cell successfully face condition oxidative stress by molecular mechanisms that are currently being studied our laboratory. contribute protection afforded fruit- vegetable-rich diets against diseases, such cardiovascular disease, which excess production reactive oxygen species (ROS) has been implicated causal or contributory factor.