Physiological Concentration of H2O2 Supports Dopamine Neuronal Survival via Activation of Nrf2 Signaling in Glial Cells.

摘要: Traditionally, hydrogen peroxide (H2O2) was formed from cellular oxidative metabolism and often viewed as toxic waste. In fact, H2O2 a benefit messenger for neuron-glia signaling synaptic transmission. Thus, double-edged sword neuroprotection vs. neurotoxicity produced by difficult to define. Nuclear factor erythroid 2-related 2 (Nrf2) has been implicated an intracellular regulator of neuronal growth. Inactivation Nrf2 participated in the development Parkinson's disease (PD). suitable activation essential prevention treatment PD. This study aimed explore whether H2O2-conferred neuroprotective effects support survival. were added into primary neuron-glia, neuron-astroglia neuron-microglia co-cultures concentration- time-dependent manners. increased dopamine (DA) survival addition, glial cells involved H2O2-supported DA with following phenomenons. First, activated pathway. Second, generated beneficial but not neuron-enriched cultures. Third, silence abolished demonstrated that physiological concentration via cells. Our data permit re-evaluate role pathogenesis therapeutic strategies