Induction of copulatory behavior in sexually inactive rats by naloxine.

作者: G. Gessa , E Paglietti , B. Quarantotti

DOI: 10.1126/SCIENCE.432642

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摘要: The intraventricular injection of D-alanine-methionine-enkephalinamide (D-Ala2-Met-enkephalinamide), a synthetic analog Met-enkephalin that is resistant to enzymatic degradation, inhibits copulatory behavior in sexually vigorous male rats doses which do not influence motor activity or feeding behavior. This effect prevented by naloxone, specific inhibitor opioid receptors. In addition, injections naloxone induce inactive rats. These results suggest endorphins play an important role the regulation sexual

参考文章(11)
C. Pert, A Pert, J. Chang, B. Fong, (D-Ala2)-Met-enkephalinamide: a potent, long-lasting synthetic pentapeptide analgesic Science. ,vol. 194, pp. 330- 332 ,(1976) , 10.1126/SCIENCE.968485
H YANG, J HONG, E COSTA, Regional distribution of LEU and MET enkephalin in rat brain. Neuropharmacology. ,vol. 16, pp. 303- 307 ,(1977) , 10.1016/0028-3908(77)90112-5
M. Meglio, Y. Hosobuchi, H. H. Loh, J. E. Adams, C. H. Li, beta-Endorphin: behavioral and analgesic activity in cats. Proceedings of the National Academy of Sciences. ,vol. 74, pp. 774- 776 ,(1977) , 10.1073/PNAS.74.2.774
G Urca, H Frenk, J. Liebeskind, A. Taylor, Morphine and enkephalin: analgesic and epileptic properties. Science. ,vol. 197, pp. 83- 86 ,(1977) , 10.1126/SCIENCE.867056
R. Guillemin, N. Ling, R. Burgus, Isolation, primary structure, and synthesis of α-endorphin and γ-endorphin, two peptides of hypothalamic-hypophysial origin with morphinomimetic activity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 73, pp. 3942- 3946 ,(1976) , 10.1073/PNAS.73.11.3942
J. Walker, G. Berntson, C. Sandman, D. Coy, A. Schally, A. Kastin, An analog of enkephalin having prolonged opiate-like effects in vivo. Science. ,vol. 196, pp. 85- 87 ,(1977) , 10.1126/SCIENCE.190683
John A. H. Lord, Angela A. Waterfield, John Hughes, Hans W. Kosterlitz, Endogenous opioid peptides: multiple agonists and receptors Nature. ,vol. 267, pp. 495- 499 ,(1977) , 10.1038/267495A0
Rabi Simantov, Michael J. Kuhar, Gavril W. Pasternak, Solomon H. Snyder, The regional distribution of a morphine-like factor enkephalin in monkey brain Brain Research. ,vol. 106, pp. 189- 197 ,(1976) , 10.1016/0006-8993(76)90086-X
E.T. Wei, L.F. Tseng, H.H. Loh, Choh Hao Li, Comparison of the behavioral effects of β-endorphin and enkephalin analogs Life Sciences. ,vol. 21, pp. 321- 327 ,(1977) , 10.1016/0024-3205(77)90512-4